GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs8030605 | 1 | rs55942364 | chr15:56512961 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.84 | 9.5E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs346923 | 1 | rs55942533 | chr4:53372881 | KIAA0114 | chr4:53578621-53580305:+ | 0.17 | 3.42 | 0.000674 | Biochemical measures |
| THCA | cis | rs12047808 | 1 | rs55942649 | chr1:179482604 | C1orf125 | chr1:179335107-179523868:+ | 0.33 | 3.81 | 0.00016 | Multiple sclerosis (age of onset) |
| THCA | cis | rs867186 | 1 | rs55946144 | chr20:33629610 | PROCR | chr20:33758727-33765164:+ | -0.34 | -5.59 | 3.77E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs55946144 | chr20:33629610 | TRPC4AP | chr20:33590215-33680618:- | 0.27 | 3.37 | 0.000808 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs60843830 | 1 | rs55946380 | chr2:268293 | SH3YL1 | chr2:218138-264810:- | -0.95 | -26.48 | 8.61E-96 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs3126085 | 1 | rs55957623 | chr1:152223196 | FLG | chr1:152274651-152297679:- | 0.28 | 4.27 | 2.36E-5 | Atopic dermatitis |
| THCA | cis | rs3126085 | 1 | rs55957623 | chr1:152223196 | HRNR | chr1:152184558-152196669:- | -0.42 | -5.68 | 2.36E-8 | Atopic dermatitis |
| THCA | cis | rs8030605 | 1 | rs55957636 | chr15:56526620 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.51 | 0.000485 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs55957636 | chr15:56526620 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.81 | 1.12E-8 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs6982751 | 1 | rs55958006 | chr8:10812144 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.5 | 0.000501 | Asthma and hay fever |
| THCA | cis | rs55962025 | 1 | rs55962025 | chr4:3112109 | C4orf44 | chr4:3250767-3265839:+ | -0.32 | -6.72 | 5.23E-11 | Parental longevity (mother's age at death) |
| THCA | cis | rs55962025 | 1 | rs55962025 | chr4:3112109 | GRK4 | chr4:2965343-3042474:+ | -0.2 | -3.46 | 0.000599 | Parental longevity (mother's age at death) |
| THCA | cis | rs875971 | 1 | rs55962648 | chr7:65625751 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.28 | 2.23E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs55962648 | chr7:65625751 | GUSB | chr7:65425675-65447246:- | -0.27 | -5.32 | 1.61E-7 | Aortic root size |